Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Di Stasi, Antonio; Tey, Siok‐Keen; Dotti, Gianpietro; Fujita, Yuriko; A. Kennedy‐Nasser, Alana; Martinez, Caridad; Straathof, Karin; Liu, Enli; Durett, April; Grilley, Bambi; Liu, Hao; Colli Cruz, Carolina; Savoldo, Barbara; P. Gee, Adrian; Schindler, John; A. Krance, Robert; E. Heslop, Helen; M. Spencer, David; M. Rooney, Cliona; K. Brenner, Malcolm

doi:10.1056/nejmoa1106152

Public

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Published in New England Journal of Medicine • Nov 2, 2011

Authors:

Antonio Di Stasi

Siok‐Keen Tey

Gianpietro Dotti

Abstract

BACKGROUND: Cellular therapies could play a role in cancer treatment and regenerative medicine if it were possible to quickly eliminate the infused cells in case of adverse events. We devised an inducible T-cell safety switch that is based on the fusion of human caspase 9 to a modified human FK-bind...

Subject

Suicide gene

Medicine

Stem cell

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