Artemisinin‐Induced Dormancy in<i>Plasmodium falciparum</i>: Duration, Recovery Rates, and Implications in Treatment Failure

Teuscher, Franka; L. Gatton, Michelle; Chen, Nanhua; M. Peters, Jennifer; E. Kyle, Dennis; Cheng, Qin

doi:10.1086/656476

Public

Artemisinin‐Induced Dormancy inPlasmodium falciparum: Duration, Recovery Rates, and Implications in Treatment Failure

Published in The Journal of Infectious Diseases • Sep 23, 2010

Authors:

Franka Teuscher

Michelle L. Gatton

Nanhua Chen

Abstract

BACKGROUND: Despite the remarkable activity of artemisinin and its derivatives, monotherapy with these agents has been associated with high rates of recrudescence. The temporary arrest of the growth of ring-stage parasites (dormancy) after exposure to artemisinin drugs provides a plausible explanati...

Subject

Artemisinin

Dihydroartemisinin

Mefloquine

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