Changes in antithrombin and fibrinogen levels during induction chemotherapy with L-asparaginase in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Use of supportive coagulation therapy and clinical outcome: the CAPELAL study.

M, Hunault-Berger; P, Chevallier; M, Delain; CE, Bulabois; S, Bologna; M, Bernard; I, Lafon; J, Cornillon; A, Maakaroun; A, Tizon; B, Padrazzi; N, Ifrah; Y, Gruel

doi:10.3324/haematol.12948

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Changes in antithrombin and fibrinogen levels during induction chemotherapy with L-asparaginase in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Use of supportive coagulation therapy and clinical outcome: the CAPELAL study.

Shared by NobleBlocks on Aug 25, 2008 • 12:00 AM UTC

Authors:

Hunault-Berger M

Chevallier P

Delain M

Abstract

Background The effects of L-asparaginase on hemostasis during induction chemotherapy are less defined in adults than in children. We, therefore, studied the effects of L-asparaginase in adult patients.Design and methods This was a retrospective analysis of 214 patients treated with L-asparaginase (7...

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