HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Baldeyron, Céline; Soria, Gastón; Roche, Danièle; Cook, Adam; Almouzni, Geneviève

doi:10.1083/jcb.201101030

Public

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Published in The Journal of Cell Biology • Apr 4, 2011

Authors:

Céline Baldeyron

Gastón Soria

Danièle Roche

Abstract

Heterochromatin protein 1 (HP1), a major component of constitutive heterochromatin, is recruited to DNA damage sites. However, the mechanism involved in this recruitment and its functional importance during DNA repair remain major unresolved issues. Here, by characterizing HP1α dynamics at laser-ind...

Subject

Heterochromatin protein 1

Heterochromatin

Euchromatin

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