Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

Geun Lee, Chun; J. Homer, Robert; Zhu, Zhou; Lanone, Sophie; Wang, Xiaoman; Koteliansky, Victor; Michael Shipley, J.; Gotwals, Philip; Noble, Paul; Chen, Qingsheng; M. Senior, Robert; A. Elias, Jack

doi:10.1084/jem.194.6.809

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Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

Shared by NobleBlocks on Sep 17, 2001 • 12:00 AM UTC

Authors:

Chun Geun Lee

Robert J. Homer

Zhou Zhu

Abstract

Interleukin (IL)-13 is a key mediator of tissue fibrosis caused by T helper cell type 2 inflammation. We hypothesized that the fibrogenic effects of IL-13 are mediated by transforming growth factor (TGF)-β. To test this hypothesis we compared the regulation of TGF-β in lungs from wild-type mice and ...

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