Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury

Mori, Kiyoshi; Thomas Lee, H.; Rapoport, Dana; R. Drexler, Ian; Foster, Kirk; Yang, Jun; M. Schmidt‐Ott, Kai; Chen, Xia; Yi Li, Jau; F. Weiss, Stacey; Mishra, Jaya; H. Cheema, Faisal; Markowitz, Glenn; Suganami, Takayoshi; Sawai, Kazutomo; Mukoyama, Masashi; L. Kunis, Cheryl; D. D’Agati, Vivette; Devarajan, Prasad; Barasch, Jonathan

doi:10.1172/jci23056

Public

Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury

Published in Journal of Clinical Investigation • Mar 1, 2005

Authors:

Kiyoshi Mori

H. Thomas Lee

Dana Rapoport

Abstract

Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors into epithelial tubules. In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney ...

Subject

Siderophore

Lipocalin

Kidney

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