Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by Surgery Versus Up-Front Surgery in Locally Advanced Resectable Oral Squamous Cell Carcinoma

Zhong, Lai-ping; Zhang, Chen-ping; Ren, Guo-xin; Guo, Wei; N. William, William; Sun, Jian; Zhu, Han-guang; Tu, Wen-yong; LI, Jiang; Cai, Yi-li; Wang, Li-zhen; Fan, Xin-dong; Wang, Zhong-he; Hu, Yong-jie; Ji, Tong; Yang, Wen-jun; Ye, Weimin; Li, Jun; He, Yue; Wang, Yan-an; Xu, Li-Qun; Wang, Bo-song; S. Kies, Merrill; Jack Lee, J.; N. Myers, Jeffrey; Zhang, Zhiyuan

doi:10.1200/jco.2012.43.8820

Public

Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by Surgery Versus Up-Front Surgery in Locally Advanced Resectable Oral Squamous Cell Carcinoma

Published in Journal of Clinical Oncology • Nov 6, 2012

Authors:

Lai-ping Zhong

Chen-ping Zhang

Guo-xin Ren

Abstract

PURPOSE: To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced resectable oral squamous cell carcinoma (OSCC). PATIENTS AND METHO...

Subject

Medicine

Docetaxel

Induction chemotherapy

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