α-Synuclein Locus Triplication Causes Parkinson's Disease

B. Singleton, A.; Singleton, Andrew; J. Farrer, Matthew; Johnson, Janel; Singleton, Andrew; Singleton, A.; Hague, Stephen; M. Kachergus, Jennifer; Hulihan, Mary; Peuralinna, Terhi; Dutra, A.; Nussbaum, Robert; Lincoln, S.; Crawley, Anthony; Hanson, M; M. Maraganore, Demetrius; H. Adler, Charles; Cookson, Mark; D. Muenter, Manfred; Fortuna Baptista, Maria; W. Miller, David; Blancato, Jan; Hardy, John; Gwinn, Katrina

doi:10.1126/science.1090278

Public

α-Synuclein Locus Triplication Causes Parkinson's Disease

Published in Science • Oct 30, 2003

Authors:

A. B. Singleton

Andrew Singleton

Matthew J. Farrer

Abstract

Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition,

Subject

Parkinson's disease

Locus (genetics)

Disease

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