Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers

Cobbold, Mark; Khan, Naeem; Pourgheysari, Batoul; Tauro, Sudhir; McDonald, Dorothy; Osman, Husam; Assenmacher, Mario; Billingham, Lucinda; G. Steward, Colin; Crawley, Charles; Olavarría, Eduardo; M. Goldman, John; Chakraverty, Ronjon; Mahendra, Premini; Craddock, Charles; Moss, Paul

doi:10.1084/jem.20040613

Public

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers

Published in The Journal of Experimental Medicine • Aug 1, 2005

Authors:

Mark Cobbold

Naeem Khan

Batoul Pourgheysari

Abstract

Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant cause of morbidity and mortality. Adoptive transfe...

Subject

CD8

Adoptive cell transfer

Immunology

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