Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans

Esposito, Katherine; Nappo, Francesco; Marfella, Raffaele; Giugliano, Giovanni; Giugliano, Francesco; Ciotola, Myriam; Quagliaro, Lisa; Ceriello, Antonio; Giugliano, Dario

doi:10.1161/01.cir.0000034509.14906.ae

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Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans

Shared by NobleBlocks on Oct 15, 2002 • 12:00 AM UTC

Authors:

Katherine Esposito

Francesco Nappo

Raffaele Marfella

Abstract

Background— Circulating levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are elevated in diabetic patients. We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-α, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT)...

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