Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

Zhou, Jie; Chu, Hin; Li, Cun; Ho‐Yin Wong, Bosco; Cheng, Zhongshan; Kwok‐Man Poon, Vincent; Sun, Tianhao; Choi-Yi Lau, Candy; Kak‐Yuen Wong, Kenneth; Yu‐Wai Chan, Jimmy; Fuk‐Woo Chan, Jasper; Kai‐Wang To, Kelvin; Chan, Kwok‐Hung; Zheng, Bo‐Jian; Yuen, Kwok‐Yung

doi:10.1093/infdis/jit504

Public

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

Published in The Journal of Infectious Diseases • Sep 24, 2013

Authors:

Jie Zhou

Hin Chu

Cun Li

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) infection caused severe pneumonia and multiorgan dysfunction and had a higher crude fatality rate (around 50% vs. 10%) than SARS coronavirus (SARS-CoV) infection. To understand the pathogenesis, we studied viral replication, cytokine/chemokine ...

Subject

Chemokine

Immunology

Pathogenesis

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