CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling

Arnaud, Marie-Pierre; Vallée, Audrey; Robert, Guillaume; Bonneau, Jacinthe; Le Roy, Christine; Varin‐Blank, Nadine; Rio, Anne-Gaëlle; Troadec, Marie‐Bérengère; Galibert, Marie‐Dominique; Gandemer, Virginie

doi:10.1182/blood-2015-02-628560

Public

CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling

Published in Blood • Aug 29, 2015

Authors:

Marie-Pierre Arnaud

Audrey Vallée

Guillaume Robert

Abstract

CD9, a member of the tetraspanin family, has been implicated in hematopoietic and leukemic stem cell homing. We investigated the role of CD9 in the dissemination of B acute lymphoblastic leukemia (B-ALL) cells, by stably downregulating CD9 in REH and NALM6 cells. CD9 expression was associated with h...

Subject

RAC1

Nod

Cancer research

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