The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

Blažek, Dalibor; Kohoutek, Jiří; Bartholomeeusen, Koen; Johansen, Eric; Hulinková, Petra; Luo, Zeping; Cimermančič, Peter; Ule, Jernej; Matija Peterlin, B.

doi:10.1101/gad.16962311

Public

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

Published in Genes & Development • Oct 15, 2011

Authors:

Dalibor Blažek

Jiří Kohoutek

Koen Bartholomeeusen

Abstract

Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of transcription. In this study, we identified a 70-kDa Cyclin K (CycK) that binds Cdk12 and Cdk13 to form two different complexes (CycK/Cdk12 or CycK/Cdk13) in human cells. The CycK/Cdk12 complex regulates phosph...

Subject

Biology

DNA damage

DNA repair

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