Long-Term Control of HIV by <i>CCR5</i> Delta32/Delta32 Stem-Cell Transplantation

Hütter, Gero; Nowak, Daniel; Mossner, Maximilian; Ganepola, Susanne; Müßig, Arne; Allers, Kristina; Schneider, Thomas; Hofmann, Jörg; Kücherer, Claudia; Blau, Olga; Wolfgang Blau, Igor; K. Hofmann, Wolf; Thiel, Eckhard

doi:10.1056/nejmoa0802905

Public

Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation

Published in New England Journal of Medicine • Feb 11, 2009

Authors:

Gero Hütter

Daniel Nowak

Maximilian Mossner

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells fro...

Subject

Medicine

Discontinuation

Transplantation

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