Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic <i>Arabidopsis</i> seeds

Van Droogenbroeck, Bart; Cao, Jingyuan; Stadlmann, Johannes; Altmann, Friedrich; Colanesi, Sarah; Hillmer, Stefan; G. Robinson, David; Van Lerberge, Els; Terryn, Nancy; Van Montagu, Marc; Liang, Mifang; Depicker, Ann; De Jaeger, Geert

doi:10.1073/pnas.0609997104

Public

Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds

Published in Proceedings of the National Academy of Sciences • Jan 16, 2007

Authors:

Bart Van Droogenbroeck

Jingyuan Cao

Johannes Stadlmann

Abstract

Production of high-value recombinant proteins in transgenic seeds is an attractive and economically feasible alternative to conventional systems based on mammalian cells and bacteria. In contrast to leaves, seeds allow high-level accumulation of recombinant proteins in a relatively small volume and ...

Subject

KDEL

Periplasmic space

Endoplasmic reticulum

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