A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

Klopstock, Thomas; Yu‐Wai‐Man, Patrick; Dimitriadis, Konstantinos; Rouleau, Jacinthe; Heck, Suzette; Bailie, Maura; Atawan, Alaa; Chattopadhyay, Sandip; Schubert, Marion; Garip, Aylin; Kernt, Marcus; Petraki, Diana; Rummey, Christian; Leinonen, Mika; Metz, Günther; G. Griffiths, Philip; Meier, Thomas; F. Chinnery, Patrick

doi:10.1093/brain/awr170

Public

A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

Published in Brain • Jul 23, 2011

Authors:

Thomas Klopstock

Patrick Yu‐Wai‐Man

Konstantinos Dimitriadis

Abstract

Major advances in understanding the pathogenesis of inherited metabolic disease caused by mitochondrial DNA mutations have yet to translate into treatments of proven efficacy. Leber's hereditary optic neuropathy is the most common mitochondrial DNA disorder causing irreversible blindness in young ad...

Subject

Idebenone

Leber's hereditary optic neuropathy

Medicine

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