Homologues of the <i>Caenorhabditis elegans</i> Fox-1 Protein Are Neuronal Splicing Regulators in Mammals

G. Underwood, Jason; L. Boutz, Paul; D. Dougherty, Joseph; Stoilov, Peter; L. Black, Douglas

doi:10.1128/mcb.25.22.10005-10016.2005

Public

Homologues of the Caenorhabditis elegans Fox-1 Protein Are Neuronal Splicing Regulators in Mammals

Published in Molecular and Cellular Biology • Oct 31, 2005

Authors:

Jason G. Underwood

Paul L. Boutz

Joseph D. Dougherty

Abstract

A vertebrate homologue of the Fox-1 protein from C. elegans was recently shown to bind to the element GCAUG and to act as an inhibitor of alternative splicing patterns in muscle. The element UGCAUG is a splicing enhancer element found downstream of numerous neuron-specific exons. We show here that m...

Subject

Biology

RNA splicing

Exon

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