Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.

BJ, Bosch; BE, Martina; Der Zee R, Van; J, Lepault; BJ, Haijema; C, Versluis; AJ, Heck; Groot R, De; AD, Osterhaus; PJ, Rottier

doi:10.1073/pnas.0400576101

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Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.

Shared by NobleBlocks on May 18, 2004 • 12:00 AM UTC

Authors:

Bosch BJ

Martina BE

Van Der Zee R

Abstract

The coronavirus SARS-CoV is the primary cause of the life-threatening severe acute respiratory syndrome (SARS). With the aim of developing therapeutic agents, we have tested peptides derived from the membrane-proximal (HR2) and membrane-distal (HR1) heptad repeat region of the spike protein as inhib...

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