Identification and Functional Characterization of Brainstem Cannabinoid CB<sub>2</sub>Receptors

D. Van Sickle, Marja; Duncan, Marnie; J. Kingsley, Philip; Mouihate, Abdeslam; Urbani, Paolo; Mackie, Ken; Stella, Nephi; Makriyannis, Alexandros; Piomelli, Daniele; S. Davison, Joseph; J. Marnett, Lawrence; Di Marzo, Vincenzo; J. Pittman, Quentin; D. Patel, Kamala; A. Sharkey, Keith

doi:10.1126/science.1115740

Public

Identification and Functional Characterization of Brainstem Cannabinoid CB2Receptors

Published in Science • Oct 13, 2005

Authors:

Marja D. Van Sickle

Marnie Duncan

Philip J. Kingsley

Abstract

The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arac...

Subject

Endocannabinoid system

Cannabinoid receptor

Receptor

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