Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, Xiaoying; Xiang, Xiaoyu; E. Grizzle, William; Sun, Dongmei; Zhang, Shuangqin; C. Axtell, Robert; Ju, Songwen; Mu, Jiangyao; Zhang, Lifeng; Steinman, Lawrence; R. Miller, Donald; Zhang, Huang-Ge

doi:10.1038/mt.2011.164

Public

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Published in Molecular Therapy • Sep 13, 2011

Authors:

Xiaoying Zhuang

Xiaoyu Xiang

William E. Grizzle

Abstract

In this study, exosomes used to encapsulate curcumin (Exo-cur) or a signal transducer and activator of transcription 3 (Stat3) inhibitor, i.e., JSI124 (Exo-JSI124) were delivered noninvasively to microglia cells via an intranasal route. The results generated from three inflammation-mediated disease ...

Subject

Experimental autoimmune encephalomyelitis

Myelin oligodendrocyte glycoprotein

Inflammation

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