MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

Ji, Qing; Hao, Xinbao; Zhang, Min; Tang, Wenhua; Yang, Meng; Li, Ling; Xiang, Debing; DeSano, Jeffrey; T. Bommer, Guido; Fan, Daiming; R. Fearon, Eric; S. Lawrence, Theodore; Xu, Liang

doi:10.1371/journal.pone.0006816

Public

MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

Published in PLoS ONE • Aug 27, 2009

Authors:

Qing Ji

Xinbao Hao

Min Zhang

Abstract

BACKGROUND: MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of the three miRNA miR-34 family members was recently found to be directly regulated...

Subject

Pancreatic cancer

Clonogenic assay

Cancer stem cell

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