Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

Kawamura, Kazuhiro; Cheng, Yuan; Suzuki, Nao; Deguchi, Masashi; Sato, Yorino; Takae, Seido; Ho, Chi-hong; Kawamura, Nanami; Tamura, Midori; Hashimoto, Shu; Sugishita, Yodo; Morimoto, Yoshiharu; Hosoi, Yoshihiko; Yoshioka, Nobuhito; Ishizuka, Bunpei; J.W. Hsueh, Aaron

doi:10.1073/pnas.1312830110

Public

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

Published in Proceedings of the National Academy of Sciences • Sep 30, 2013

Authors:

Kazuhiro Kawamura

Yuan Cheng

Nao Suzuki

Abstract

Primary ovarian insufficiency (POI) and polycystic ovarian syndrome are ovarian diseases causing infertility. Although there is no effective treatment for POI, therapies for polycystic ovarian syndrome include ovarian wedge resection or laser drilling to induce follicle growth. Underlying mechanisms...

Subject

Hippo signaling pathway

Infertility

Ovarian reserve

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