Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

T. Liu, Philip; Stenger, Steffen; Li, Huiying; Wenzel, Linda; H. Tan, Belinda; R. Krutzik, Stephan; Teresa Ochoa, Marîa; Schauber, Jürgen; Wu, Kent; Meinken, Christoph; L. Kamen, Diane; Wagner, Manfred; Bals, Robert; Steinmeyer, Andreas; Zügel, Ulrich; L. Gallo, Richard; Eisenberg, David; Hewison, Martin; W. Hollis, Bruce; S. Adams, John; R. Bloom, Barry; L. Modlin, Robert

doi:10.1126/science.1123933

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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

Published in Science • Feb 23, 2006

Authors:

Philip T. Liu

Steffen Stenger

Huiying Li

Abstract

In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...

Subject

Cathelicidin

Innate immune system

Antimicrobial peptides

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