Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

Genovese, Giulio; J. Friedman, David; D. Ross, Michael; Lecordier, Laurence; Uzureau, Pierrick; I. Freedman, Barry; W. Bowden, Donald; D. Langefeld, Carl; K. Oleksyk, Tarás; L. Knob, Andrea; J. Bernhardy, Andrea; J. Hicks, Pamela; W. Nelson, George; Vanhollebeke, Benoît; A. Winkler, Cheryl; B. Kopp, Jeffrey; Pays, Etienne; R. Pollak, Martin

doi:10.1126/science.1193032

Public

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

Published in Science • Jul 15, 2010

Authors:

Giulio Genovese

David J. Friedman

Michael D. Ross

Abstract

African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on ...

Subject

Focal segmental glomerulosclerosis

Kidney disease

Odds ratio

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