Amino acid substitutions in the Candida albicans sterol  5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence

Morio, Florent; Pagniez, Fabrice; Lacroix, Céline; Miègeville, M.; Le Pape, Patrice

doi:10.1093/jac/dks186

Public

Amino acid substitutions in the Candida albicans sterol 5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence

Published in Journal of Antimicrobial Chemotherapy • Jun 7, 2012

Authors:

Florent Morio

Fabrice Pagniez

Céline Lacroix

Abstract

OBJECTIVES: To determine the mechanisms responsible for fluconazole resistance in two Candida albicans isolates (CAAL2 and CAAL76) recovered from two hospitalized patients after fluconazole prophylaxis. METHODS: MICs of fluconazole and voriconazole were determined by the broth microdilution method (...

Subject

Ergosterol

Fluconazole

Biology

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