Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age

Bejon, Philip; Lusingu, John; Olotu, Ally; Leach, Amanda; Lievens, Marc; Vekemans, Johan; Mshamu, Salum; Lang, Trudie; Gould, Jayne; Dubois, Marie‐Claude; Demoitié, Marie‐Ange; Stallaert, Jean-Francois; Vansadia, Preeti; Carter, Terrell; Njuguna, Patricia; Awuondo, Ken; Malabeja, Anangisye; Abdul, Omar; Gesase, Samwel; Mturi, Neema; J. Drakeley, Chris; Savarese, Barbara; Villafana, Tonya; Ripley Ballou, W.; Cohen, Joe; M. Riley, Eleanor; M. Lemnge, Martha; Marsh, Kevin; von Seidlein, Lorenz

doi:10.1056/nejmoa0807381

Public

Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age

Published in New England Journal of Medicine • Dec 8, 2008

Authors:

Philip Bejon

John Lusingu

Ally Olotu

Abstract

BACKGROUND: Plasmodium falciparum malaria is a pressing global health problem. A previous study of the malaria vaccine RTS,S (which targets the circumsporozoite protein), given with an adjuvant system (AS02A), showed a 30% rate of protection against clinical malaria in children 1 to 4 years of age. ...

Subject

Malaria

Medicine

Malaria vaccine

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