Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Brunet, Anne; B. Sweeney, Lora; Fitzhugh Sturgill, James; F. Chua, Katrin; L. Greer, Paul; Lin, Yingxi; Tran, Hien; E. Ross, Sarah; Mostoslavsky, Raúl; Cohen, Haim; Hu, Linda; Cheng, Hwei-Ling; P. Jedrychowski, Mark; P. Gygi, Steven; Sinclair, David; W. Alt, Frederick; E. Greenberg, Michael

doi:10.1126/science.1094637

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Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Published in Science • Feb 23, 2004

Authors:

Anne Brunet

Lora B. Sweeney

James Fitzhugh Sturgill

Abstract

The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of...

Subject

FOXO3

Longevity

Transcription factor

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