The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.

D, Rossi; M, Cerri; C, Deambrogi; E, Sozzi; S, Cresta; S, Rasi; Paoli L, De; V, Spina; V, Gattei; D, Capello; F, Forconi; F, Lauria; G, Gaidano

doi:10.1158/1078-0432.ccr-08-1630

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The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.

Shared by NobleBlocks on Feb 1, 2009 • 12:00 AM UTC

Authors:

Rossi D

Cerri M

Deambrogi C

Abstract

Purpose Del17p13 predicts poor outcome and chemorefractoriness in chronic lymphocytic leukemia (CLL). Conversely, it is unknown whether TP53 mutations carry any prognostic value independent of del17p13. We tested the independent prognostic value of TP53 mutations in CLL.Experimental design The study...

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