Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Langmead, Ben; Trapnell, Cole; Pop, Mihai; L. Salzberg, Steven

doi:10.1186/gb-2009-10-3-r25

Public

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Published in Genome biology • Mar 4, 2009

Authors:

Ben Langmead

Cole Trapnell

Mihai Pop

Abstract

Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of approximately 1.3 gigabytes. Bowtie extends prev...

Subject

Biology

Human genetics

Human genome

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