Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac Outcomes

E. Lipshultz, Steven; L. Miller, Tracie; R. Lipsitz, Stuart; Neuberg, Donna; E. Dahlberg, Suzanne; D. Colan, Steven; B. Silverman, Lewis; Henkel, Jacqueline; I. Franco, Vivian; L. Cushman, Laura; L. Asselin, Barbara; A. Clavell, Luis; H. Athale, Uma; Michon, Bruno; Laverdière, Caroline; A. Schorin, Marshall; Larsen, Eric; Usmani, Naheed; E. Sallan, Stephen

doi:10.1542/peds.2012-0727

Public

Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac Outcomes

Published in PEDIATRICS • Nov 20, 2012

Authors:

Steven E. Lipshultz

Tracie L. Miller

Stuart R. Lipsitz

Abstract

BACKGROUND AND OBJECTIVES: Doxorubicin, effective against many malignancies, is limited by cardiotoxicity. Continuous-infusion doxorubicin, compared with bolus-infusion, reduces early cardiotoxicity in adults. Its effectiveness in reducing late cardiotoxicity in children remains uncertain. We determ...

Subject

Medicine

Cardiotoxicity

Bolus (digestion)

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