High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis

Demedts, Maurits; Behr, Juergen; Buhl, Roland; Costabel, Ulrich; Dekhuijzen, Richard; M. Jansen, Henk; MacNee, William; Thomeer, Michiel; Wallaert, B.; Laurent, François; G. Nicholson, Andrew; Verbeken, Eric; Verschakelen, Johny; Flower, C.D.R.; Capron, Frédérique; Petruzzelli, Stefano; De Vuyst, Paul; M.M. van den Bosch, Jules; Rodríguez-Becerra, Eulogio; Corvasce, Giuseppina; Lankhorst, Ida; Sardina, Marco; Montanari, Mauro

doi:10.1056/nejmoa042976

Public

High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis

Published in New England Journal of Medicine • Nov 23, 2005

Authors:

Maurits Demedts

Juergen Behr

Roland Buhl

Abstract

BACKGROUND: Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis. METHODS: We conducted a double-blind, randomized, placebo-controlled multicenter study that assessed the effectiveness over one year of a high oral dose of acetylcysteine (600 mg three times daily) add...

Subject

Medicine

DLCO

Prednisone

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