Biological activity of the <i>Helicobacter pylori</i> virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Higashi, Hideaki; Tsutsumi, Ryouhei; Fujita, Akiko; Yamazaki, Shiho; Asaka, Masahiro; Azuma, Takeshi; Hatakeyama, Masanori

doi:10.1073/pnas.222375399

Public

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Published in Proceedings of the National Academy of Sciences • Oct 21, 2002

Authors:

Hideaki Higashi

Ryouhei Tsutsumi

Akiko Fujita

Abstract

Helicobacter pylori is a causative agent of gastritis and peptic ulcer. cagA(+) H. pylori strains are more virulent than cagA(-) strains and are associated with gastric carcinoma. The cagA gene product, CagA, is injected by the bacterium into gastric epithelial cells and subsequently undergoes tyros...

Subject

CagA

Helicobacter pylori

Tyrosine phosphorylation

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!