Ketoconazole in Cushing's Disease: Is It Worth a Try?

Castinetti, Frédéric; Guignat, Laurence; Giraud, Pauline; Müller, Marie; Kamenický, Peter; Drui, D.; Caron, Philippe; Luca, Fiorina; Donadille, Bruno; Vantyghem, Marie‐Christine; Bihan, H.; Delemer, Brigitte; Raverot, Gérald; Motte‐Signoret, Emmanuelle; Philippon, Mélanie; Morange, Isabelle; Conte‐Devolx, B.; Quinquis, Laurent; Martinie, Monique; Vezzosi, Delphine; Le Bras, M.; Baudry, Camille; Christin-Maître, Sophie; Goichot, Bernard; Chanson, Philippe; Young, Jacques; Chabre, Olivier; Tabarin, Antoine; Bertherat, Jérôme; Brue, Thierry

doi:10.1210/jc.2013-3628

Public

Ketoconazole in Cushing's Disease: Is It Worth a Try?

Published in The Journal of Clinical Endocrinology & Metabolism • Jan 28, 2014

Authors:

Frédéric Castinetti

Laurence Guignat

Pauline Giraud

Abstract

BACKGROUND: The use of ketoconazole has been recently questioned after warnings from the European Medicine Agencies and the Food and Drug Administration due to potential hepatotoxicity. However, ketoconazole is frequently used as a drug to lower circulating cortisol levels. Several pharmacological a...

Subject

Ketoconazole

Medicine

Hypokalemia

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