Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

Pieters, Grégory; Taglang, Céline; Bonnefille, Eric; Gutmann, Torsten; Puente, Céline; Berthet, Jean‐Claude; Dugave, Christophe; Chaudret, Bruno; Rousseau, Bernard

doi:10.1002/anie.201307930

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Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

Shared by NobleBlocks on Nov 19, 2013 • 12:00 AM UTC

Authors:

Grégory Pieters

Céline Taglang

Eric Bonnefille

Abstract

Abstract An efficient H/D exchange method allowing the deuteration of pyridines, quinolines, indoles, and alkyl amines with D 2 in the presence of Ru@PVP nanoparticles is described. By a general and simple procedure involving mild reaction conditions and simple filtration to recover the labeled prod...

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