A Genome-Wide Association Study Identifies <i>LIPA</i> as a Susceptibility Gene for Coronary Artery Disease

S. Wild, Philipp; Zeller, Tanja; Schillert, Arne; Szymczak, Silke; Sinning, Christoph; Deiseroth, Arne; B. Schnabel, Renate; Lubos, Edith; Keller, Till; Eleftheriadis, Medea; Bickel, Christoph; J. Rupprecht, Hans; Wilde, Sandra; Rossmann, Heidi; Diemert, Patrick; Adrienne Cupples, L.; Perret, Claire; Erdmann, Jeanette; Stark, Klaus; E. Kleber, Marcus; E. Epstein, Stephen; F. Voight, Benjamin; Kuulasmaa, Kari; Li, Mingyao; Schäfer, Arne; Klopp, Norman; S. Braund, Peter; B. Sager, Hendrik; Demissie, Serkalem; Proust, Carole; R. König, Inke; Wichmann, H.-Erich; Reinhard, Wibke; M. Hoffmann, Michael; Virtamo, Jarmo; Susan Burnett, Mary; S. Siscovick, David; Wiklund, Per; Qu, Liming; Eddine El Mokthari, Nour; R. Thompson, John; Peters, Annette; V. Smith, Albert; Yon, Emmanuelle; Baumert, Jens; Hengstenberg, Christian; März, Winfried; Amouyel, Philippe; M. Devaney, Joseph; M. Schwartz, Stephen; Saarela, Olli; N. Mehta, Nehal; C. Rubin, Deborah; Silander, Kaisa; S. Hall, Alistair; Ferrières, Jean; B. Harris, Tamara; Melander, Olle; Kee, Frank; Håkonarson, Håkon; Schrezenmeir, Juergen; Guðnason, Vilmundur; Elosúa, Roberto; Arveiler, Dominique; Evans, Alun; J. Rader, Daniel; Illig, Thomas; Schreiber, Stefan; C. Bis, Joshua; Altshuler, David; Kavousi, Maryam; C. M. Witteman, J.; G. Uitterlinden, André; Hofman, Albert; R. Folsom, Aaron; Barbalić, Maja; Boerwinkle, Eric; Kathiresan, Sekar; P. Reilly, Muredach; J. O’Donnell, Christopher; J. Samani, Nilesh; Schunkert, Heribert; Cambien, François; J. Lackner, Karl; Tiret, Laurence; Salomaa, Veikko; Münzel, Thomas; Ziegler, Andreas; Blankenberg, Stefan

doi:10.1161/circgenetics.110.958728

Public

A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease

Published in Circulation Cardiovascular Genetics • May 24, 2011

Authors:

Philipp S. Wild

Tanja Zeller

Arne Schillert

Abstract

BACKGROUND: eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). METHODS AND RESULTS: In a genom...

Subject

Single-nucleotide polymorphism

Genome-wide association study

Expression quantitative trait loci

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