Requirement for IL-13 Independently of IL-4 in Experimental Asthma

Grünig, Gabriele; Warnock, Martha; E. Wakil, Adil; Venkayya, Rajeev; Brombacher, Frank; M. Rennick, Donna; Sheppard, Dean; Mohrs, Markus; D. Donaldson, Debra; M. Locksley, Richard; B. Corry, David

doi:10.1126/science.282.5397.2261

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Requirement for IL-13 Independently of IL-4 in Experimental Asthma

Shared by NobleBlocks on Dec 18, 1998 • 12:00 AM UTC

Authors:

Gabriele Grünig

Martha Warnock

Adil E. Wakil

Abstract

The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the α chain of the IL-4 receptor, ameliorated ...

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