Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

E. Nelson, David; Ihekwaba, Adaoha; C. Elliott, Malcolm; R. Johnson, James; A. Gibney, C.; Foreman, Bo; Nelson, Glyn; Sée, Violaine; A. Horton, Caroline; G. Spiller, David; W. Edwards, Steven; P. McDowell, Heather; Unitt, John; Sullivan, Elaine; L. Grimley, Rachel; Benson, Neil; Broomhead, D.S.; B. Kell, Douglas; White, Michael

doi:10.1126/science.1099962

Public

Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

Published in Science • Oct 21, 2004

Authors:

David E. Nelson

Adaoha Ihekwaba

Malcolm C. Elliott

Abstract

Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscill...

Subject

Dynamics (music)

Gene expression

Gene

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