Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

E. Nelson, D.; E. C. Ihekwaba, A.; Elliott, M.; R. Johnson, J.; A. Gibney, C.; E. Foreman, B.; Nelson, G.; See, V.; A. Horton, C.; G. Spiller, D.; W. Edwards, S.; P. McDowell, H.; F. Unitt, J.; Sullivan, E.; Grimley, R.; Benson, N.; Broomhead, D.; B. Kell, D.; R. H. White, M.

doi:10.1126/science.1099962

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Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

Shared by NobleBlocks on Oct 22, 2004 • 12:00 AM UTC

Authors:

D. E. Nelson

A. E. C. Ihekwaba

M. Elliott

Abstract

Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB tran...

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