Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Prabhakar, Uma; Maeda, Hiroshi; K. Jain, Rakesh; M. Sevick‐Muraca, Eva; C. Zamboni, William; C. Farokhzad, Omid; T. Barry, Simon; Gabizón, Alberto; Grodzinski, Piotr; C. Blakey, David

doi:10.1158/0008-5472.can-12-4561

Public

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Published in Cancer Research • Feb 20, 2013

Authors:

Uma Prabhakar

Hiroshi Maeda

Rakesh K. Jain

Abstract

Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This phenomenon, enhanced permeability and retention (EPR), has been the basis of nanotechnology platforms to deliver dru...

Subject

Nanomedicine

Drug delivery

Drug

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