Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development

Hirasawa, Ryutaro; Chiba, Hatsune; Kaneda, Masahiro; Tajima, Shoji; Li, En; Jaenisch, Rudolf; Sasaki, Hiroyuki

doi:10.1101/gad.1667008

Public

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development

Published in Genes & Development • Jun 15, 2008

Authors:

Ryutaro Hirasawa

Hatsune Chiba

Masahiro Kaneda

Abstract

Parental origin-specific DNA methylation regulates the monoallelic expression of the mammalian imprinted genes. The methylation marks or imprints are established in the parental germline and maintained throughout embryonic development. However, it is unclear how the methylation imprints are maintain...

Subject

Biology

Genomic imprinting

DNA methylation

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