Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

M.Y. Kong, Stephanie; K.K. Chan, Brian; Park, Jin‐Sung; J. Hill, Kathryn; B. Aitken, Jade; Cottle, Louise; Farghaian, Hovik; R. Cole, Adam; A. Lay, Peter; M. Sue, Carolyn; A. Cooper, Antony

doi:10.1093/hmg/ddu099

Public

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

Published in Human Molecular Genetics • Mar 6, 2014

Authors:

Stephanie M.Y. Kong

Brian K.K. Chan

Jin‐Sung Park

Abstract

α-Synuclein plays a central causative role in Parkinson's disease (PD). Increased expression of the P-type ATPase ion pump PARK9/ATP13A2 suppresses α-Synuclein toxicity in primary neurons. Our data indicate that ATP13A2 encodes a zinc pump; neurospheres from a compound heterozygous ATP13A2(-/-) pati...

Subject

Biology

Parkinson's disease

Externalization

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