The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

Malinow, M.R.; Javier Nieto, F.; D. Kruger, Warren; Barton Duell, P.; L. Hess, David; Gluckman, R.; C. Block, Peter; Holzgang, C.R.; Anderson, Paul; Seltzer, D.; Upson, Barbara; Lin, Qing

doi:10.1161/01.atv.17.6.1157

Public

The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

Published in Arteriosclerosis Thrombosis and Vascular Biology • Jun 1, 1997

Authors:

M.R. Malinow

F. Javier Nieto

Warren D. Kruger

Abstract

Elevated concentration of plasma total homocysteine (tHcy) is a common risk factor for arterial occlusive diseases. Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5, 10-methylenetetrahydrofolate red...

Subject

Multivitamin

Methylenetetrahydrofolate reductase

Homocysteine

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