The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

Malinow, M.R.; Nieto, F.J.; Kruger, W.D.; Duell, P.B.; Hess, D.L.; Gluckman, R.A.; Block, P.C.; Holzgang, C.R.; Anderson, P.H.; Seltzer, D.; Upson, B.; Lin, Q.R.

doi:10.1161/01.atv.17.6.1157

Public

The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

Shared by NobleBlocks on Jun 1, 1997 • 12:00 AM UTC

Authors:

M.R. Malinow

F.J. Nieto

W.D. Kruger

Abstract

Abstract Elevated concentration of plasma total homocysteine (tHcy) is a common risk factor for arterial occlusive diseases. Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5,10-methylenetetrahydrofo...

Discussions