Comprehensive molecular characterization of gastric adenocarcinoma

J. Bass, Adam; Thórsson, Vésteinn; Shmulevich, Ilya; M. Reynolds, Sheila; Miller, Michael; Bernard, Brady; Thórsson, Vésteinn; Iype, Lisa; Kramer, Roger; Kreisberg, Richard; Rovira, Hector; Tasman, Natalie; Hinoue, Toshinori; O Laird, P; Shen, Hui; J. Weisenberger, Daniel; Bootwalla, Moiz; H. Lai, Phillip; J. Triche, Timothy; Van Den Berg, David; Curtis, Christina; Schultz, Nikolaus; Weinhold, Nils; B. Arman Askoy, r; Ciriello, Giovanni; Dresdner, Gideon; Gao, Jianjiong; Gross, Benjamin; Jacobsen, Anders; Lee, William; Ramírez, Ricardo; Sander, Chris; Şenbabaoğlu, Yasin; Sinha, Rileen; Onur Sumer, S.; Sun, Yichao; Shen, Ronglai; P. Kelsen, David; Y. Janjigian, Yelena; Bowlby, Reanne; Chu, Andy; Kasaian, Katayoon; J. Mungall, Andrew; Gordon Robertson, A.; Sipahimalani, Payal; Ally, Adrian; Balasundaram, Miruna; Birol, İnanç; Brooks, Denise; S.N. Butterfield, Yaron; Carlsen, Rebecca; Chu, Justin; Chuah, Eric; E. Chun, Hye-Jung; Clarke, Amanda; Dhalla, Noreen; Guin, Ranabir; A. Holt, Robert; J.M. Jones, Steven; Lee, Darlene; A. Li, Haiyan; L. Lim, Emilia; Ma, Yussanne; A. Marra, Marco; Mayo, Michael; A. Moore, Richard; Mungall, Karen; Ming Nip, Ka; E. Schein, Jacqueline; Tam, Angela; Thiessen, Nina; Cherniack, Andrew; Getz, Gad; Liu, Yingchun; S. Noble, Michael; Pedamallu, Chandra; Sougnez, Carrie; Taylor‐Weiner, Amaro; S. Lawrence, Michael; Cibulskis, Kristian; Lichtenstein, Lee; Fisher, Sheila; Gabriel, Stacey; S. Lander, Eric; Beroukhim, Rameen; L. Carter, Scott; D. Cherniack, Andrew; Cho, Juok; DiCara, Daniel; Frazer, Scott; Gehlenborg, Nils; I. Heiman, David; Jung, Joonil; Kim, Jaegil; Lin, Pei; Meyerson, Matthew; I. Ojesina, Akinyemi; Sekhar Pedamallu, Chandra; Saksena, Gordon; E. Schumacher, Steven; Stojanov, Petar; Tabak, Barbara; Voet, Doug; Rosenberg, Mara; Zack, Travis; Zhang, Hailei; Zou, Lihua; A. Murray, Bradley; Akbani, Rehan; Lee, Ju‐Seog; Liu, Wenbin; Ling, Shiyun; Rao, Arvind; N. Weinstein, John; B. Mills, Gordon; Kim, Sangbae; Lu, Yiling; B. Mills, Gordon; Yang, Da; Zhang, Wei; Pantazi, Angeliki; Parfenov, Michael; Santoso, Netty; Ren, Xiaojia; Hadjipanayis, Angela; G. Seidman, Jonathan; Kucherlapati, Raju; L. Gulley, Margaret; Blanca Piazuelo, M.; Schneider, Barbara; Kim, Jihun; S. Park, Young; Boussioutas, Alex; Sheth, Margi; A. Demchok, John; Eley, Greg; Shaw, Kenna; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; C. Zenklusen, Jean; S. Rabkin, Charles; Constanza Camargo, M.; Willis, Joseph; Ng, Sam; Haussler, David; M. Stuart, Joshua; S. Garman, Katherine; G. Beer, David; Pennathur, Arjun; Dhir, Rajiv; D. Luketich, James; J. Landreneau, Rodney; J. Raphael, Benjamin; Wu, Hsin-Ta; D.M. Leiserson, Mark; D. Odze, Robert; K. Kim, Hark; Bowen, Jay; Leraas, Kristen; M. Lichtenberg, Tara; Weaver, Stephanie; D. Black, Aaron; A Carney, J; M. Gastier-Foster, Julie; Helsel, Carmen; McAllister, Cynthia; C. Ramirez, Nilsa; R. Tabler, Teresa; Wise, Lisa; Zmuda, Erik; D. McLellan, Michael; Ding, Li; Niu, Beifang; Wiznerowicz, Maciej; Brzezinski, Jakub; Ibbs, Matthew; Korski, Konstanty; Kycler, Witold; Łaźniak, Radosław; Leporowska, Ewa; Maćkiewicz, Andrzej; Murawa, Dawid; Murawa, P.; Spychała, Arkadiusz; Maria Suchorska, Wiktoria; Tatka, Honorata; Teresiak, M.; Sakai, Ryo; Protopopov, Alexei; Zhang, Jianhua; S. Mahadeshwar, Harshad; Tang, Jiabin; Seth, Sahil; Song, Xingzhi; A. Bristow, Christopher; Chin, Lynda; Verhaak, Roeland; Lee, Semin; Yang, Lixing; Wei Xu, Andrew; Xi, Ruibin; J. Park, Peter; B. Baylin, Stephen; G. Herman, James; S. Taylor, Barry; Penny, Robert; Crain, Daniel; Gardner, Johanna; Lau, Kevin; Curely, Erin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Shelton, Troy; Shelton, Candace; E. Sherman, Mark; Kemkes, Ariane; Curley, Erin; C. Benz, Christopher; Lee, Jae-Hyuk; Kv, Fedosenko; M. Manikhas, Georgy; Potapova, Olga; Voronina, Olga; Dk, Belyaev; V Dolzhansky, O; Kimryn Rathmell, W.; Abdel‐Misih, Raafat; Bennett, Joseph; R. Brown, Jennifer; Iacocca, Mary; Rabeno, Brenda; Young Kwon, Sun; Alexopoulou, Iakovina; Engel, Jay; M.S. Bartlett, John; Albert, Monique; Park, Do-Youn; Cho, Eunjung; Ladanyi, Marc; Tang, Laura; J. McCall, Shannon; Cheong, Jae-Ho; Ajani, Jaffer; Alonso, Shelley; Ayala, Brenda; A. Jensen, Mark; Pihl, T; Raman, Rohini; Walton, Jessica; Wan, Yunhu; Davidsen, Tanja; M. Hutter, Carolyn; J. Sofia, Heidi; Burton, Robert; Chudamani, Sudha; Liu, J

doi:10.1038/nature13480

Public

Comprehensive molecular characterization of gastric adenocarcinoma

Published in Nature • Jul 23, 2014

Authors:

Adam J. Bass

Vésteinn Thórsson

Ilya Shmulevich

Abstract

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genom...

Subject

Microsatellite instability

Cancer research

Chromosome instability

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