Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Termeer, Christian; Benedix, Frauke; P. Sleeman, Jonathan; Fieber, Christina; Voith, Ursula; Ahrens, Thomas; Miyake, Kensuke; A. Freudenberg, Marina; Galanos, C.; C. Simon, Jan

doi:10.1084/jem.20001858

Public

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Published in The Journal of Experimental Medicine • Jan 7, 2002

Authors:

Christian Termeer

Frauke Benedix

Jonathan P. Sleeman

Abstract

Low molecular weight fragmentation products of the polysaccharide of Hyaluronic acid (sHA) produced during inflammation have been shown to be potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages. Here we report that sHA induces maturation of DCs via the Toll-like ...

Subject

Cell biology

Toll-like receptor

Receptor

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!