An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

Bonassi, Stefano; Znaor, Ariana; Ceppi, Marcello; Lando, Cecilia; P. Chang, W.; Holland, Nina; Kirsch‐Volders, Micheline; Zeiger, Errol; Ban, Sadayuki; Barale, Roberto; Paola Bigatti, Maria; Bolognesi, Claudia; Cebulska-Wasilewska, A.; Fabianova, Eleonora; Fucic, A.; Hagmar, Lars; Joksiċ, Gordana; Martelli, Antonietta; Migliore, Lucia; Mirkova, E.; Rosaria Scarfı̀, Maria; Zijno, Andrea; Norppa, Hannu; Fenech, Michael

doi:10.1093/carcin/bgl177

Public

An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

Published in Carcinogenesis • Aug 18, 2006

Authors:

Stefano Bonassi

Ariana Znaor

Marcello Ceppi

Abstract

The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospe...

Subject

Micronucleus test

Medicine

Biomarker

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