mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

O’Reilly, Kathryn; Rojo, F.; She, Qing‐Bai; B. Solit, David; B. Mills, Gordon; L. Smith, Debra; A. Lane, Heidi; Hofmann, Francesco; J. Hicklin, Daniel; L. Ludwig, Dale; Baselga, José; Rosen, Neal

doi:10.1158/0008-5472.can-05-2925

Public

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Published in Cancer Research • Feb 1, 2006

Authors:

Kathryn O’Reilly

F. Rojo

Qing‐Bai She

Abstract

Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an mTOR-dependent loss in insulin receptor substrate-1 expression leading to feedback down-regulation of signaling thro...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

Receptor tyrosine kinase

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