Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

R. Lockman, Paul; K. Mittapalli, Rajendar; S. Taskar, Kunal; Rudraraju, Vinay; Gril, Brunilde; A. Bohn, Kaci; E. Adkins, Chris; Roberts, Amanda; R. Thorsheim, Helen; A. Gaasch, Julie; Huang, Suyun; Palmieri, Diane; S. Steeg, Patricia; R. Smith, Quentin

doi:10.1158/1078-0432.ccr-10-1564

Public

Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

Published in Clinical Cancer Research • Sep 9, 2010

Authors:

Paul R. Lockman

Rajendar K. Mittapalli

Kunal S. Taskar

Abstract

PURPOSE: Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The blood-tumor barrier (BTB) is compromised in many brain metastases; however, the extent to which this influences chemother...

Subject

Medicine

Brain metastasis

Doxorubicin

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