HER-2/<i>neu</i> Analysis in Archival Tissue Samples of Human Breast Cancer: Comparison of Immunohistochemistry and Fluorescence In Situ Hybridization

Lebeau, Annette; Deimling, Daniela; Kaltz, Christine; Sendelhofert, Andrea; Iff, Anette; Luthardt, Beate; Untch, Michael; Löhrs, U.

doi:10.1200/jco.2001.19.2.354

Public

HER-2/neu Analysis in Archival Tissue Samples of Human Breast Cancer: Comparison of Immunohistochemistry and Fluorescence In Situ Hybridization

Published in Journal of Clinical Oncology • Jan 15, 2001

Authors:

Annette Lebeau

Daniela Deimling

Christine Kaltz

Abstract

PURPOSE: The objective of our study was to compare the methods used in the literature to analyze HER-2/neu status on archival breast cancer tissue. Therefore, a series of antibodies was evaluated to assess their immunohistochemical (IHC) sensitivity in correlation to gene amplification determined by...

Subject

Immunohistochemistry

Fluorescence in situ hybridization

Gene duplication

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