Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Genovese, Giulio; K. Kähler, Anna; E. Handsaker, Robert; Lindberg, Johan; A. Rose, Samuel; F. Bakhoum, Samuel; Chambert, Kimberly; Mick, Eran; M. Neale, Benjamin; Fromer, Menachem; Purcell, Shaun; Svantesson, Oscar; Landén, Mikael; Höglund, Martin; Lehmann, Sören; B. Gabriel, Stacey; L. Moran, Jennifer; S. Lander, Eric; F. Sullivan, Patrick; Sklar, Pamela; Grönberg, Henrik; M. Hultman, Christina; A. McCarroll, Steven

doi:10.1056/nejmoa1409405

Public

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Published in New England Journal of Medicine • Nov 26, 2014

Authors:

Giulio Genovese

Anna K. Kähler

Robert E. Handsaker

Abstract

BACKGROUND: Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. METHODS: We analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 ...

Subject

Cancer

Medicine

Somatic cell

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