<i>IDH1</i>and<i>IDH2</i>Mutations in Gliomas

Yan, Hai; Williams Parsons, D.; Jin, Genglin; E. McLendon, Roger; Ahmed Rasheed, B.; Yuan, Weishi; Kos, Ivan; Batinic̈‐Haberle, Ines; Jones, Siân; J. Riggins, Gregory; S. Friedman, Henry; H. Friedman, Allan; A. Reardon, David; E. Herndon, James; W. Kinzler, Kenneth; E. Velculescu, Victor; Vogelstein, Bert; D. Bigner, Darell

doi:10.1056/nejmoa0808710

Public

IDH1andIDH2Mutations in Gliomas

Published in New England Journal of Medicine • Feb 18, 2009

Authors:

Hai Yan

D. Williams Parsons

Genglin Jin

Abstract

BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gli...

Subject

IDH2

IDH1

Isocitrate dehydrogenase

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