Genetic Risk and Carcinogen Exposure: a Common Inherited Defect of the Carcinogen-Metabolism Gene Glutathione S-Transferase M1 (GSTM1) That Increases Susceptibility to Bladder Cancer

A. Bell, Douglas; A. Taylor, Jack; F. Paulson, David; N. Robertson, Cary; L. Mohler, James; W. Lucier, George

doi:10.1093/jnci/85.14.1159

Public

Genetic Risk and Carcinogen Exposure: a Common Inherited Defect of the Carcinogen-Metabolism Gene Glutathione S-Transferase M1 (GSTM1) That Increases Susceptibility to Bladder Cancer

Published in JNCI Journal of the National Cancer Institute • Jul 21, 1993

Authors:

Douglas A. Bell

Jack A. Taylor

David F. Paulson

Abstract

BACKGROUND: Numerous studies have associated bladder cancer with exposure to carcinogens present in tobacco smoke and other environmental or occupational exposures. Approximately 50% of all humans inherit two deleted copies of the GSTM1 gene which encodes for the carcinogen-detoxification enzyme glu...

Subject

Carcinogen

Glutathione S-transferase

Bladder cancer

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